Can I use metacells data to estimate Scissor cells?

[JHovelly]

Thank you for your excellent algorithm, Can I use metacell data, which means a metacell is a sum of dozens of single cells, as the imput. In my opinion, metacell data can improve the correlation between single cells data and bulk data because dropout effect can be decreased. It is appreciated if you could answer my question! Best wishes! J Hovelly.

[sunduanchen]

Hi Hovelly,

Yes. No problem. When I handle the single-cell data with numerous cells (e.g. over 100,000 cells), I will add a preprocessing step to make some metacells or pseudo-cells.

Best, Duanchen

On Sat, 22 Apr 2023 at 14:03, JHovelly @.***> wrote:

Thank you for your excellent algorithm, Can I use metacell data, which means a metacell is a sum of dozens of single cells, as the imput. In my opinion, metacell data can improve the correlation between single cells data and bulk data because dropout effect can be decreased. It is appreciated if you could answer my question! Best wishes! J Hovelly.

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