foldseek
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Cluster based on e-value/tmscore ?
Expected Behavior
When i run the easy-cluster wih a set of rfdiffusion generated structures, i obeserve that with foldseek cluster program which based e-value will give the ooposite trend, compared to cluster based on tm-score threshold(tmscore cutoff 0.6)
Current Behavior
The light blue is the total count of scaffold of each length, the drak blue is the count of clusters, why when use e-values there will be less cluster when length increase while use tm-score the trend is opposite?
what;s your recommondation cluster creterion when calculates the structure diversity of structure generation model?