foldseek
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interpretation of 'fident' output
Hello, thank you for this great tool.
Currently we are trying to redo the HFSP curve using foldseek instead of mmseqs2. When using identical data we noticed a shift downwards in % sequence identity using foldseek compared to mmseqs2.
My question is: Is 'fident' reported by foldseek based on the AA residues in protein sequences (like mmseqs2) or is it based on the new structural alphabet of 3Di states?
Edit: we noticed a downwards shift in foldseek, not upwards, in terms of % sequence identity