CellChat
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compare probabilities across samples
I have > 60 scRNA-seq samples and did CellChat separately for each of them. For example, patient 1 has three L1_R1 interactions with the following communication probabilities:
- of 0.01 from cell_type1 to cell_type2,
- 0.02 from cell_type1 to cell_type3,
- and 0.04 from cell_type1 to cell_type4.
Then I would say the chance of L1_R1 interaction happening in patient 1 is 1-(0.990.980.96) = 0.0687.
Patient 2 has 1 cell_type1 to cell_type4 L1_R1 interaction with communication probability of 0.02.
Is it correct to compare patient 1’s 0.0687 chance with patient 2’s 0.02 chance of having interaction L1_R1?