snakemake-wrappers
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Mutect2 issue that raises false positive calls by 20%
Is your feature request related to a problem? Please describe. Knowing the open issue on GATK github: Mutect2: drop in SNV specificity/precision between v.4.1.8.1 and 4.1.9.0)
Knowing the final answer of GATK team:
Sorry for the long wait on this issue, which we do take seriously! Unfortunately as mentioned above we have extremely limited resources for Mutect2 maintenance at the moment due to our focus on Mutect3, which we see as the long-term solution to this and other issues. You should definitely continue to run 4.1.8.0 until this is resolved, if at all possible.
Describe the solution you'd like
Drop Mutect2 wrapper environment from 4.2 to 4.1.8.0.
Describe alternatives you've considered
Add a warning on documentation.
Additional context
There is no known release date for Mutect3.