MetaMorpheus icon indicating copy to clipboard operation
MetaMorpheus copied to clipboard

Published 20 hours ago • verified publisher icon smith-chem-wisc

Multiprotease search and target/decoy collisions

Open Alexander-Sol opened this issue 6 months ago • 0 comments

PR #2394 added functionality to eliminate decoy peptides that are identical to target peptides. However, this only works for single-protease searches. If there are multiple proteases, then it is possible to have identical target and decoy peptides again.

Possible solves for this issue:

  • Move protein db loading to the SearchTask
  • consider all possible proteases in the MetaMorpheusTask
  • Decoy on the fly

Alexander-Sol avatar Aug 27 '24 16:08 Alexander-Sol