Spout4Unity
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Performance Issue
There's a noticeable spike in performance at regular intervals of about every 15 frames for me. I'm testing using the sender scene included in the demo.
Here's a snapshot of the profiler with four senders.

Which becomes much more apparent with eight senders. I'd expect a general drop in framerate, but this is more of a stuttering effect.

Which Unity version and graphics card?
Unity 5.3.3 and NVIDIA GeForce 750M, I've got access to a 980ti and a 780 if you'd like some further testing done, I'm seeing the same issue on these too.