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Scalable genetics toolkit

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Hi, I am running a big simulation with a million people and I'd like to calculate the genealogical relatedness between them. I tried running sgkit and unfortunately, when I hit...

We might even want to make a full website as part of this switch? Either way I'll look into Cloudflare's DNS admin interface soon...

documentation

In `vcf_to_zarr`, specifying `max_alt_alleles` as smaller than the actual maximum is meant to truncate the alleles dimension (with a warning). However, if there is an INFO field with length `R`...

bug
IO

There's no good reason for returning bytes rather than utf8 unicode strings I think --- it can only lead to bugs in user code and inconsistencies in string handling (anyone...

bug

Updates for vcf-zarr spec change: https://github.com/pystatgen/vcf-zarr-spec/issues/14 Almost working, I think the main issues remaining are in the round-trip tests. Nobody uses Character columns in the real world I think, so...

A couple of recent publications generalize the VanRaden estimator to mixed-ploidy populations. - [Batista et al 2022](https://link.springer.com/article/10.1007/s00122-021-03994-w) - [Bilton et al 2024](https://link.springer.com/article/10.1007/s00122-024-04568-2) The later goes into the derivation in more...

enhancement

- [x] Fixes #1227 - [x] Tests added - [x] User visible changes (including notable bug fixes) are documented in `changelog.rst`

Not expected to pass - mainly to record failing tests for #1234 - [ ] Fixes #xxxx - [ ] Tests added - [ ] User visible changes (including notable...

Tim made some fixes in #1228, but there are still some more

upstream

There's an alpha release available now that can be installed using `pip install --pre` https://pypi.org/project/zarr/3.0.0a0/

upstream