seraphzl

Same issue. ``` $ ulimit -n 1048576 ```

The code set a low value, you can change this to a larger one, or comment this line to cancel this limit. https://github.com/ma-compbio/Higashi/blob/1333de29ac1d808906d81409176c7dbd0cf2558f/higashi/Higashi_wrapper.py#L452 Solved!