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bmcite progenitor cell types

Open dy-lin opened this issue 2 years ago • 1 comments

I am trying to sort bone marrow cells into these categories:

celltypes <- c("HSC/MPP", "LMPP", "CMP", "CLP", "GMP", "MEP")

In bmcite, there are some progenitor cells labelled differently: Prog_B 1, Prog_B 2, Prog_DC, Prog_Mk, andProg_RBC.

[1] "Prog_RBC" "GMP"      "Prog_B 2" "Prog_Mk"  "HSC"      "LMPP"     "Prog_DC"  "Prog_B 1"

From my understanding:

  • Prog_RBC can be recoded as "MEP"
  • Prog_Mk can be recoded as "MEP"
  • Prog_B 1/2 can be recoded as "CLP"
  • Prog_DC can be of either myeloid (CMP) or lymphoid (CLP) lineage

Is there anything in the generation of this dataset or cell type labelling that dictates whether the Prog_DC in this dataset should should be recoded as from myeloid or lymphoid?

dy-lin avatar Aug 12 '22 20:08 dy-lin

I have the same confusion, does anyone know?

MikaQiao avatar Sep 30 '22 15:09 MikaQiao