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multiallelic splitting of with ALT asterisk

Open dwaggott opened this issue 7 years ago • 2 comments

What's the expected behavior when applying norm -m- to split multiple alleles when there is a * ALT?

After filtering against gnomad to get rare variants I'm left with a large number of high AF variants with * ALTs.

My understanding is that an asterisk is used to represent a deleted allele when combined with another variant. An asterisk could represent multiple underlying deletions at different positions. After splitting I'm tempted to just delete them.

dwaggott avatar Apr 13 '17 22:04 dwaggott