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Non-CPython support for C-extensions
From https://github.com/realpython/python-guide/blob/master/docs/starting/which-python.rst#cpython :
If you are writing open-source Python code and want to reach the widest possible audience, targeting CPython is best. To use packages which rely on C extensions to function, CPython is your only implementation option.
PyPy now supports (some/all?) C extensions http://doc.pypy.org/en/latest/extending.html
Jython supports C extensions through JyNI: https://github.com/Stewori/JyNI
IronPython supports C extensions now? https://ironpython-test.readthedocs.io/en/latest/extending/extending.html