phenopacket-schema
phenopacket-schema copied to clipboard
Documentation, inconsistencies in TNM use
The v2 documentation provides different options for TNM findings:
clinical_tnm_findinginDisease, with the description "child terms of NCIT:C48232 (Cancer TNM Finding)" and examples in the documentation (but partially using the prefixes for pathological TNM)
clinicalTnmFinding:
- id: "NCIT:C48766"
label: "pT2b Stage Finding"
- id: "NCIT:C48750"
label: "pN2 Stage Finding"
pathological_tnm_findinginBiosamplew/o example in the documentation (so far) but inline notes in the.proto
// ARGO mapping specimen::pathological_t_category
// ARGO mapping specimen::pathological_n_category
// ARGO mapping specimen::pathological_m_category
While I assume the duality between clinical and pathological for the different scopes of subject.diseases and biosample reflects different optional uses,
- it is not clear if e.g. for all TNM annotations NCIT:C48232 should be used (probably?)
- that there is a need for "clinical" versus "pathological" categories, since e.g.
pN2indicates a pathological finding
I would suggest to keep (if needed) TNM properties in disease and biosample, but w/o explicit designation of clin/path. In this case also different observations (clinical. patho) can be collected (e.g. a patient may have pre- and post-OP stages but no specific biosample data etc.). Also, the ARGO references may be informative but should be secondary to term usage documentation (or moved to extended documentation).