which one should I used to calculate logFC?

[YichaoOU]

Currently, I'm using transcript_tpm = sleuth_to_matrix(so,"obs_norm","tpm") to get a normalized gene expression matrix and then use log2((transcript_tpm[,"treatment_mean"]+1e-100)/(transcript_tpm[,"control_mean"]+1e-100)) as the logFC.

Is it correct?

Thanks, Yichao