Andrew

@pd3 I tested this option and it still took ~2 hours. To see if it might be related to other features that have been added in the past I tested...

Thanks @pd3, this is very helpful. I'll try out your suggestions.

I believe so. Our cluster is down at the moment; I can double-check later this week.

Yes, I ran `bcftools view` with the VCF and it prints out the VCF with no errors or warnings.

Another possible addition is gnomad exomes update to 2.1: http://gnomad.broadinstitute.org/downloads Update -- never mind, just saw you already mentioned gnomad exomes in your first list.

Will this be a separate genetic model, or will it be part of the existing comp_hets? The approach seems fine to me for now (others should weigh in too).

This is a whole genome VCF, but I'll try to narrow it down. Regarding using list with float... technically if the VCF is normalized and decomposed, and the user hasn't...

I guess if we have a list in a FLOAT field that would probably mess up any SQL queries you performed on that field?

Ah, I see. Okay, I tried that, it worked.

Any plan to do this CADD update in gemini in the near future? This would be really helpful for us. It would also be nice to include indels (scores for...