upheno
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obophenotype
abnormal response to chemical
I need a pattern for abnormal response to chemical for example:
DDPHENO:0000041 | aberrant response to N-Phenylthiourea DDPHENO:0000358 aberrant response to cAMP DDPHENO:0000359 increased response to cAMP DDPHENO:0000360 decreased response to cAMP DDPHENO:0000361 abolished response to cAMP DDPHENO:0000362 aberrant response to nocodazole
Thanks!
Some examples from the MP that may help with this pattern(s):
The MP has a bunch of these terms but we have split them into abnormal physiological response and abnormal behavioral response. Only the most general physiological response ones currently have definitions, for 'abnormal physiological response to xenobiotic' the EQ is: 'has part' some ('response to' and ('inheres in' some xenobiotic) and ('has modifier' some abnormal)) The increased and decreased sensitivity terms in MGI use 'has part' some ('decreased/increased sensitivity toward' and (towards some xenobiotic) and ('has modifier' some abnormal)) Where we have 'xenobiotic' we could substitute in the appropriate CHEBI term. The 'response to' relation in PATO is defined as 'A quality inhering in a bearer by virtue of the whether the bearer's disposition to react to a stimulus or an agent.' Not sure why the MP has 'decreased/increased sensitivity toward' rather than hyperresponsive to/hyporesponsive to decreased sensitivity toward is defined as 'A sensitivity toward an external stimulus which is lower than normal/average.' in PATO
The behavioral ones have definitions along the lines of: 'has part' some (quality and ('inheres in' some 'behavioral response to xenobiotics') and ('has modifier' some abnormal)) Where 'behavioral response to xenobiotics' is a term from NBO. he NBO has a number of substance specific terms.
We could also look at the GO response to stimulus branch but this is limited to physiological response to stimulus. The GO behavior branch has a number of 'behavioral response to X' but a generic behavior response term.
