Cleanly separate respiratory system epithelia

[dosumis]

Aim: Edit respiratory system epithelia partonomy to have separate terms for:

1. alveolar epithelium (AT1, AT2)
2. terminal/respiratory bronchiole epithelium (Includes AT0, RAS)
3. conducting airway epithelium- (goblet, tuft, multiciliated, neuroendocrine, club) <--- some questions over what to call this.
4. respiratory tract gland epithelium (serous/mucous secretory cells and duct cells)
5. airway hillock (hillock cells, squamous)

The current partonomy is very tangled. Everything is under respiratory tract epithelium.

This is a problem for CL - it is very hard to separate out cell types cleanly if using inference on location to classify. However, it should be possible to separate these out.

[dosumis]

Issues:

'respiratory tract epithelium' appears to be a fusion of two different concepts. The text definition corresponds to the conducting airway epithelium:

"The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi." This fits with the MP xref on the def:

abnormal respiratory epithelium morphology http://purl.obolibrary.org/obo/MP_0010942 any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi.

the MA xref is consistent with this in that it excludes the alveolar epithelim

However, the formal def is much broader:

epithelium and 'part of' some 'respiratory tract'

This => automated classification of all the epithelia in the respiratory tract, including alveolar epithelium etc. This definition is more consistent with the the BTO xref.

2 solutions:

1. Add new term for conducting airway epithelium
2. Rename respiratory tract epithelium to conducting airway epithelium and make formal def consistent.

[github-actions[bot]]

This issue has not seen any activity in the past 6 months; it will be closed automatically one year from now if no action is taken.