obophenotype
Research: Bone marrow adipocyte literature search and definition proposal
Successfully used artl-mcp MCP server tools to search literature for bone marrow adipocyte and created a comprehensive, literature-based definition proposal.
Literature Search Results
- artl-mcp tools: Successfully retrieved 10+ relevant papers from Europe PMC database
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Key papers analyzed:
- PMID:37926488 (Wang et al., 2024) - Review on origin, biology, and hematological relationships
- PMID:34235494 (Attané et al., 2021) - BMAds isolation protocol and metabolic distinctiveness
- PMID:38961077 (Xie et al., 2024) - Role in bone homeostasis and skeletal aging
- Additional papers on hematopoietic regeneration, cancer interactions, and endocrine function
Deliverable
Created bone-marrow-adipocyte-research-proposal.md containing:
- Literature-based definition with proper PMID references (PMID:37926488, PMID:34235494, PMID:38961077)
- Proposed definition: "An adipocyte that is part of the bone marrow and is derived from bone marrow mesenchymal stromal cells. Bone marrow adipocytes are distinct from extramedullary adipose tissues and display a specific metabolism that is not recapitulated by in vitro differentiated bone marrow mesenchymal stromal cells. These cells accumulate dynamically throughout an individual's life, interact with hematopoietic cells, and contribute to bone marrow homeostasis, hematopoietic regulation, and skeletal health."
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Ontological relationships:
is_a CL_0000136 (adipocyte),part_of UBERON_0002371 (bone marrow),develops_from CL_0002540 (mesenchymal stem cell of the bone marrow) - Key characteristics confirmed from primary literature: metabolic distinctiveness, hematopoietic interactions, skeletal homeostasis role, disease associations
- Comparison with existing adipocyte terms in Cell Ontology
Status
No ontology edits made per issue requirements. Literature search complete with comprehensive references. Definition ready for review and potential ontology implementation.
Original prompt
This section details on the original issue you should resolve
<issue_title>artl-mcp test: bone marrow adipocyte</issue_title> <issue_description>Please use artl-mcp to search the literture for papers bone marrow adipopcyte . Use the results to propose referenced definition. DO NOT EDIT THE ONTOLOGY.</issue_description>
Comments on the Issue (you are @copilot in this section)
- Fixes obophenotype/cell-ontology#3542
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