obophenotype
Update type I-V otic fibrocyte terms to spiral ligament fibrocyte with enhanced definitions
Renames otic fibrocyte subtypes to reflect anatomical specificity (spiral ligament) and updates definitions with molecular/functional characteristics from recent literature (PMID:33193034, PMID:18581144, and others).
Changes
Nomenclature
- Relabeled CL_0002666-0002670 from "type 1-5 otic fibrocyte" to "type I-V spiral ligament fibrocyte"
- Preserved searchability: original names added as broad synonyms
Definitions
- Type I: Added connexin 26/30 molecular signature
- Type II: Added K+ recycling function, NKCC1/connexin expression
- Type III: Added mechanical function, contractile protein markers, "tension fibroblast" synonym
- Type IV: Added CTGF expression, tissue remodeling role
- Type V: Added COX-1 expression, vascular regulation via prostaglandins
Logical axioms
- All types:
part_ofspiral ligament (UBERON:0006725) - Type I:
adjacent_tostria vascularis of cochlear duct (UBERON:0002282)
Supporting changes
- Declared UBERON:0006725, UBERON:0002282
- Added 7 literature references across definitions
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Original prompt
This section details on the original issue you should resolve
<issue_title>Update type I-IV otic fibrocytes</issue_title> <issue_description>Use these references PMID: 33193034 PMID: 18581144
General changes
- relabel type 1-5 otic fibrocyte to type I-IV spiral ligament fibrocyte ( and add type 1-5 otic fibrocyte as broad synonyms)
- link to anatomical locations if available
- Update the definition with newer findings
https://www.perplexity.ai/search/system-role-you-are-an-expert-VQYk98iJQraFpp0QSB6Osg#0
type 1 otic fibrocyte
definition
A spiral ligament fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. In mice, expression of connexin 26 (Gjb2) and connexin 30 (Gjb6) serves as a distinguishing molecular signature (Peeleman et al., 2020).
DO NOT replace references, but instead add these to existing ones PMID: 33193034 PMID: 18581144
logical definition Add
- 'part of' some 'spiral ligament'
- 'adjacent to' some 'stria vascularis of cochlear duct'
type 2 otic fibrocyte
A spiral ligament fibrocyte that is located near the spiral prominence between the basilar crest and the stria and plays an important role in potassium recycling by actively pumping K+ from the extracellular space and facilitating transcellular K+ transport through gap junctions toward Type I fibrocytes (Berrocal et al., 2008; Peeleman et al., 2020). In mice, Type II fibrocytes express connexin 26 (Gjb2) and connexin 30 (Gjb6) as part of the mesenchymal gap junction system, as well as the Na‑K‑2Cl cotransporter NKCC1 (Peeleman et al., 2020).
DO NOT replace references, but instead add these to existing ones PMID: 19080786 PMID: 33193034
logical definition Add
- 'part of' some 'spiral ligament'
type 3 otic fibrocyte A spiral ligament fibrocyte that is located in the deepest part of the inferior spiral ligament, directly lining the bony otic capsule. Distinguished from ion-transporting Type I and II fibrocytes by its mechanical function, it utilizes actin-myosin stress fibers to maintain structural tension on the basilar membrane, which is critical for cochlear tuning. It has an elongated morphology and expresses contractile and cytoskeletal proteins in mice, including α‑smooth muscle actin, non‑muscle myosin II, caldesmon, and the water channel Aquaporin‑1(Mahendrasingam et al., 2011; Kelly et al., 2012).
DO NOT replace references, but instead add these to existing ones
PMID: 22043022 PMID: 33193034 PMID: 22476723
synonyms* tension fibroblast - exact synonym - PMID: 33193034
logical definition Add
- 'part of' some 'spiral ligament'
type 4 otic fibrocyte
A spiral ligament fibrocyte that is located in the triangular space inferior to the crista basilaris (basilar crest). This cell is spindle-shaped and expresses both NKCC1 and low levels of Na,K-ATPase (ATP1A1, ATP1B1), contributing to K⁺ recycling, though with lower transporter activity than Type II fibrocytes. Type IV fibrocytes are uniquely characterized by strong expression of connective tissue growth factor (CTGF), suggesting roles in tissue remodeling and paracrine signaling to other cochlear cells.
DO NOT replace references, but instead add these to existing ones PMID: 33193034
logical definition Add
- 'part of' some 'spiral ligament'
type 5 otic fibrocyte A spiral ligament fibrocyte located in the suprastrial region above the stria vascularis, distinguished from other fibrocyteby their unique expression of COX-1 and end-foot structures that directly contact capillaries. This fibro-vascular coupling enables Type V fibrocytes to regulate cochlear blood flow by translating Ca²⁺ signals into capillary vasodilation via COX-1-derived prostaglandins. This cell also participates in K⁺ recycling through high Na,K-ATPase expression in mice.
DO NOT replace references, but instead add these to existing ones
logical definition Add
- 'part of' some 'spiral ligament' </issue_description>
Comments on the Issue (you are @copilot in this section)
- Fixes obophenotype/cell-ontology#3408
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