obophenotype
Disease associated cells
We were wondering if disease associate cell types should have their own CL term. Ones that we've come across:
- cancer associated fibroblast (CAF)
- tumor associated macrophage (TAM)
Many immune cells are a response to disease, so we were curious if these cell type were distinct enough to warrant a new CL term.
Hi Jennifer,
The Cell Ontology primarily focuses on 'native cell', i.e. the normal cells of a healthy organism. Although we have few cell types under 'abnormal cell' (CL:0001063), in the past there were requests for tumor-associated cells, and in those cases it was finally decided that they were not going to be added. https://github.com/obophenotype/cell-ontology/issues/1471 https://github.com/DiseaseOntology/HumanDiseaseOntology/issues/1016 https://github.com/obophenotype/cell-ontology/issues/448
AFAIK the reasons for not adding the terms are still valid, but I will CC @addiehl @dosumis @cmungall for their input.
