[NTR] subtypes of tanycyte - alpha1,2; Beta 1,2

[dosumis]

Please check that the term does not already exist by using the ontology search tool OLS: https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label

alpha 1 tanycyte alpha 2 tanycyte beta 1 tanycyte beta 2 tanycyte

Synonyms (add reference(s), please)

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)

Review here: DOI: 10.1016/S0074-7696(05)47003-5

Table II has a good summary of differences in location, morphology and gene expression. Looks like location and morphology might be sufficient to distinguish.

May be worth looking back at some more classical papers - review references EM studies from the 70s.

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

Your ORCID

Additional notes or concerns

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[dosumis]

Notes - needed for:

• whole mouse brain
• ["HypoMap – a unified single cell gene expression atlas of the murine hypothalamus"] | ["https://cellxgene.cziscience.com/collections/d86517f0-fa7e-4266-b82e-a521350d6d36"] | ["https://doi.org/10.1038/s42255-022-00657-y"]

Additional refs: https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2015.00387/full https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323293/

See also:
https://cellxgene.cziscience.com/cellguide/CL_0002085 - Can we use this for an extended description for the general term?

[AvolaAmg]

@dosumis thanks for your ticket. Would you like me to add the CxG link as a database_cross_reference ? Please let me know before I turn this into a PR

Here there is the work to do for these cell types

tanycyte

A specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. A tanycyte is found in the adult brain, specifically in the third ventricle, cerebral aqueduct, spinal canal, and floor of the fourth ventricle. This cell type is involved in hormonal regulation, gatekeeping molecules between the bloodstream and cerebrospinal fluid, metabolic sensing, and regulating food intake.

has_broad_synonym radial glia-like cell PMID:29351662

has_broad_synonym residual radial glia cell PMID:29351662

has_related_synonym stretched cells https://doi.org/10.1016/B978-0-12-820584-6.00016-7

α1-tanycyte

definition: A tanycyte cell has its soma located in the ventromedial and dorsomedial nuclei of the hypothalamus. This type of tanycyte extends its protrusions close to parenchymal neurons without contacting blood vessels. It expresses the glial marker S-100β.

database_cross_reference: https://en.wikipedia.org/wiki/Tanycyte PMID:26578855 PMID:16344112

extended definition: In rodents, a1 tanycytes are known to express DARPP-32, GPR50, NA Vimentin, Connexin 43, GLT-1, GLUT1(+) (Goodman and Hajihosseini 2015; Prevot et al., 2018)

database_cross_reference: PMID:26578855

has_exact_synonym: VMH tanycyte abbreviation PMID:29351662

has_exact_synonym: DMH tanycyte abbreviation PMID:29351662

has_exact_synonym: alpha1 tanycyte database_cross_reference PMID:26578855

has_broad_synonym α-tanycyte database_cross_reference PMID:26578855

Logical definition subclass of tanycyte, expresses S100-B, part of third ventricle ependyma

taxon: mice, humans

α2-tanycyte

A type of tanycyte has its soma located in the dorsomedial arcuate nucleus of the hypothalamus. This mono-ciliated tanycyte extends its protrusion to the arcuate nucleus and expresses the glial marker S-100β.

database_cross_reference: https://en.wikipedia.org/wiki/Tanycyte PMID:29351662 PMID:26578855 PMID:16344112

additional_definition In rodents, this type of tanycyte is more developmentally advanced than alpha1 tanycytes, shows a high neurogenic competence and expresses the following markers DARPP-32, Vimentin, GPR50, Connexin-43, GLT-1, GLUT1(+) (Goodman and Hajihosseini 2015; Prevot et al., 2018)

database_cross_reference: PMID:26578855

has_related_synonym: dmARH tanycyte database_cross_reference: PMID:29351662

has_exact_synonym: alpha2 tanycyte database_cross_reference PMID:26578855

has_broad_synonym α-tanycyte database_cross_reference PMID:26578855

Logical definition subclass of tanycyte, part of arcuate nucleus of hypothalamus, expresses S100-B,

taxon: mice, humans

β1-tanycyte

A type of tanycyte that has its soma located in the lateral infundibular recess of the brain. This tanycyte has an elongated morphology with multiple microvilli extending to the third ventricle in the lateral zones of the median eminence. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH).

https://en.wikipedia.org/wiki/Tanycyte PMID:29351662 PMID:26578855 PMID:16344112

has_exact_synonym: beta1 tanycyte database_cross_reference: PMID:26578855

has_broad_synonym: β-tanycyte database_cross_reference PMID:26578855

has_related_synonym: vmARH tanycyte database_cross_reference: PMID:29351662

logical definition: subclass of tanycyte, expresses FGF-1 and FGF-2, involved in secretion of GnRH, soma location infundibular recess in the brain

taxon: mice, humans

β2-tanycyte

A type of tanycyte that has its soma located in the floor of the infundibular recess in the brain. This tanycyte has an elongated morphology with multiple microvilli extending medially and ventrally to the median eminence, contacting the pial surface and blood vessels. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH).

database_cross_reference: https://en.wikipedia.org/wiki/Tanycyte PMID:29351662 PMID:26578855 PMID:16344112

has_related_synonym: ME tanycytes database_cross_reference: PMID:29351662

has_exact_synonym: beta2 tanycyte database_cross_reference PMID:26578855

has_broad_synonym: β-tanycyte database_cross_reference PMID:26578855

Logical definition: subclass of tanycyte, expresses FGF-1 and FGF-2, involved in secretion of GnRH, soma location infundibular recess in the braincontacts pial surface and blood vessels

@JABelfiore please review content and text !

[JABelfiore]

[tanycyte] Definition is great, no amends. Database_cross_reference to be added once David confirms

has_broad_synonym radial glia-like cell PMID:29351662

Paper cited frequently uses “resemblance to radial glial cells” which means the same as “radial glia-like cell”, but can't find the specific wording in the paper.

has_broad_synonym residual radial glia cell PMID:29351662

“residual radial glia cell” does not exist in paper

However, stretched cells exist in this paper.

has_related_synonym stretched cells https://doi.org/10.1016/B978-0-12-820584-6.00016-7

Can’t access this document. Suggest replacing reference with PMID:29351662

α1-tanycyte Definition: Looks great, no amends database_cross_reference: https://en.wikipedia.org/wiki/Tanycyte confirms location in ventromedial nucleus and the dorsomedial nucleus PMID:26578855 confirms α-tanycyte processes lack blood vessel contact and that It expresses the glial marker S-100β. Confirms proximity to parenchymal neurons PMID:16344112 confirms hypothalamic location Extended definition looks good. database_cross_reference: PMID:26578855 confirms expression in rodents

has_exact_synonym: VMH tanycyte abbreviation PMID:29351662 Confirms synonym

has_exact_synonym: DMH tanycyte abbreviation PMID:29351662 Confirms synonym

has_exact_synonym: alpha1 tanycyte database_cross_reference PMID:26578855 Confirms synonym

has_broad_synonym α-tanycyte database_cross_reference PMID:26578855 Confirms synonym

Logical definition looks good

α2-tanycyte Definition looks good, no amends.

database_cross_reference: https://en.wikipedia.org/wiki/Tanycyteconfirms location in dmARH PMID:29351662 confirms location in dmARH PMID:26578855 confirms mono-ciliated PMID:16344112 confirms protrusions

Additional_definition looks good

PMID:26578855 confirms expression has_related_synonym: dmARH tanycyte database_cross_reference: PMID:29351662 confirms synonym has_exact_synonym: alpha2 tanycyte database_cross_reference PMID:26578855 confirms synonym has_broad_synonym α-tanycyte database_cross_reference PMID:26578855 confirms synonym Logical definition looks good β1-tanycyte Definition looks good, no amends. https://en.wikipedia.org/wiki/Tanycyte confirms location in median eminence PMID:29351662 confirms multiple microvilli extension into third ventricle PMID:26578855 confirms expression PMID:16344112 confirms proximity to GRH neurons has_exact_synonym: beta1 tanycyte Database_cross_reference: PMID:26578855 confirms synonym has_broad_synonym: β-tanycyte database_cross_reference PMID:26578855confirms synonym has_related_synonym: vmARH tanycyte database_cross_reference: PMID:29351662 confirms synonym logical definition: looks good subclass of tanycyte, expresses FGF-1 and FGF-2, involved in secretion of GnRH, soma location infundibular recess in the brain taxon: mice, humans β2-tanycyte Definition looks good. database_cross_reference: https://en.wikipedia.org/wiki/Tanycyte confirms median eminence location PMID:29351662 confirms FGF receptors PMID:26578855 confirms multiple villi PMID:16344112 confirms GnRH has_related_synonym: ME tanycytes database_cross_reference: PMID:29351662 confirms synonym has_exact_synonym: beta2 tanycyte database_cross_reference PMID:26578855confirms synonym has_broad_synonym: β-tanycyte database_cross_reference PMID:26578855confirms synonym

Logical definition: looks good

[AvolaAmg]

thank you @JABelfiore ! will turn this into a PR!