obophenotype
[NTR] Hillock cell of the urethra epithelium
Note - please check that the term does not already exist (check OLS: https://www.ebi.ac.uk/ols/ontologies/cl)
Preferred term label: Hillock cell of the urethra epithelium
Synonyms Hillock-like cell of the urethra epithelia Hillock-like cell of the prostatic urethra epithelium
Definition (free text, please give PubMed ID in format PMID:XXXXXX)
- PMID:31390564
- PMID:32497356
Unique epithelial cell type identified in the prostatic urethra, identified by it's transcriptional similarity to lung hilllock cells PMID:30069044 PMID:32726565 PMID:33208946 PMID:33442032
Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols/ontologies/cl): CL:1000296
What is the anatomical structure that the cell is a part of? Please check Uberon: https://www.ebi.ac.uk/ols/ontologies/uberon UBERON:0002325
Your nano-attribution (ORCID) https://orcid.org/0000-0001-7772-9578
Any additional notes or concerns Lung hillock cells are not currently annotated in Cell Ontology
@GHAStVHenry Can you make a ticket for lung hillock cells? It would be good to have that term before we proceed with this one.
I can do, that, I'm don't research lung... so all I really have is the reference to the one paper that initially ID'd the cell type...
@lubianat @GHAStVHenry @dosumis @stranddw I am currently working with Douglas Strand UT Northwestern Medical Center whose manuscripts are cited in this NTR. He is with GenitoUrinary Development Molecular Anatomy Project (GUDMAP) and is creating an Anatomical Structures, Cell Types and Biomarkers (ASCT+B) table for prostate for our HuBMAP consortia mapping project. He has a new publication https://doi.org/10.1016/j.celrep.2018.11.086 which shows "Discovery of Club and Hillock epithelia enriched in the urethra and proximal ducts" and demonstrates "a strong correlation" with similar cell types based on marker expression to equivalent cell types in lung. I'm sure he would be happy to clear up any questions. Please let me know.
Howdy @emquardokus, I worked for Doug up until almost a month ago I am the Gervaise H. Henry that's the first author on that 2018 Cell Reports paper. :-)
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Note to CL editors: I removed the automated assignments as this ticket hasn't been actually picked up, though there have been comments by @lubianat and @emquardokus ; There are 4 NTRs by the same submitter, so it'd make sense to address them all at the same time: https://github.com/obophenotype/cell-ontology/issues/1133 (urethra), https://github.com/obophenotype/cell-ontology/issues/1134 (urethra), https://github.com/obophenotype/cell-ontology/issues/1135 (prostate) and https://github.com/obophenotype/cell-ontology/issues/1171 (bronchiole).
@lubianat scratch that, I see you made a PR but it seems there was a conflict? The term isn't in CL yet. I'll assign to you. Thanks!
This issue has not seen any activity in the past 6 months; it will be closed automatically in one year from now if no action is taken.
In PR #1624, only add hillock cell and respiratory hillock cell. Still missing Hillock cell of the urethra epithelium.
Hi, @lubianat, are you planning to add this new term? If not, feel free to assign the ticket to me or assign me as a reviewer if you make a PR.
Sorry for the mess, everyone. I'll add the hillock cell of the urethra now.
@GHAStVHenry, Thank you for the contribution.
The following terms have been added to CL and will be available in the next release:
CL:0017010 ‘hillock cell of urethral epithelium’ CL:0017011 ‘hillock cell of prostatic urethral epithelium’