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Using Alt+Ref instead of true depth

Open arichards2564 opened this issue 2 years ago • 0 comments

https://github.com/mskcc/facets-suite/blob/41a01fe9afb947f38af2802cf62189e0a1061cc5/R/ccf-annotate-maf.R#L58

Here, we overwrite the true read depth with alt+ref. Normally, this doesn't change much but I've seen positions where there are 3 alleles present at a given position and the mutation being called is not the major allele and neither is the reference allele. This changes the calculation quite a bit.

arichards2564 avatar Jun 06 '22 19:06 arichards2564