Representation of chromosomal boundary regions

[mbrush]

Transferred from: NIF-11899 Original Reporter: Melissa Haendel

---

This landmark paper describes the identification of chromosomal boundary regions. http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pmc/articles/PMC3356448/

references other papers describing other types of chromosomal boundaries:

A and B compartments http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pmc/articles/PMC2858594/

Lamina-Associated Domains (LADs) http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pubmed/18463634 http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pubmed/20513434

replication time zones http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pmc/articles/PMC2813472/ http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pmc/articles/PMC2877573/

Large Organized Chromatin K9-modification (LOCK) domains http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pmc/articles/PMC2632725/

The GENO/SO should have a representation of these different types of chromosomal boundaries, and we should further identify data sources to ingest to support chromosomal level correlations of genotype to phenotype and display on the genome browser.