parallel implementations and clustering of reads

[darked89]

Hello,

there are mature, included in the major Linux distros programs such as pigz, pbizp2 and lbzip2. These compress faster while being on par on compression ratios. The last one (lbzip2) seems to be faster with decompression.

For achieving better compression ratios it does help to cluster reads based on the sequence with clumpify from BBMap. This also tends to speed up a bit with downstream mapping.

Hope it helps

DK