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Sketching paired- and single-end reads together
Hello,
I have a question about how to process a sample if it has paired- but also single-end reads: my samples have FASTQ files with paired reads (R1
and R2
) and a FASTQ files with single-end reads only (SE
), and I would like to compute pair-wise dissimilarity between all the samples in my dataset.
What would be the best strategy to do that? I wanted to concatenate R1
, R2
and SE
per sample to compute the sketches but I am not sure if this would be the recommended way.
Thanks in advance!
Best, Valentina