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Cleanup setPriorVcf

Open lima1 opened this issue 7 years ago • 0 comments

setPriorVcf grew organically and cutoffs are ad hoc and might not work well for all combinations of germline and somatic databases and their corresponding versions.

  • [ ] Use population allele frequencies, PoN counts and COSMIC counts jointly when available (e.g. cases with high allele frequencies are wrongly set to a prior of 0.5 when found in COSMIC with >= 6 counts, despite being also found in the PoN).

lima1 avatar Oct 27 '18 21:10 lima1