PureCN icon indicating copy to clipboard operation
PureCN copied to clipboard

Whitelist for homozygous deletions

Open lima1 opened this issue 7 years ago • 0 comments

The current cutoff for homozygous deletions is large because we rarely see such huge deletions at MTAP/CDKN2A. Might be better to decrease the default and add a whitelist of known deletions.

  • [ ] Query TCGA for most common deletions.

  • [ ] Provide whitelist for hg19/hg38

  • [ ] Use size distribution of whitelist for finding good size cutoffs, understand how SNP6 cutoffs translate to small targets with 150-200kb off-target bins.

  • [ ] Do not count known deletions to max.homozygous.loss cutoffs.

lima1 avatar Oct 27 '18 21:10 lima1