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Priors for private germline rate in callMutationBurden

Open lima1 opened this issue 8 years ago • 0 comments

We currently use flat priors for private variants. This can result in artificially high private germline rates in hyper-mutated samples or low rates in silent genomes, especially in high purity samples. (Thus resulting in under- and overestimating somatic rates, respectively.)

  • [ ] Provide function to estimate rate based on callMutationBurden output from many samples

  • [ ] Adjust probabilities, probably only in callMutationBurden, not in fitting.

lima1 avatar Oct 01 '17 20:10 lima1