PureCN
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Priors for private germline rate in callMutationBurden
We currently use flat priors for private variants. This can result in artificially high private germline rates in hyper-mutated samples or low rates in silent genomes, especially in high purity samples. (Thus resulting in under- and overestimating somatic rates, respectively.)
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[ ] Provide function to estimate rate based on callMutationBurden output from many samples
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[ ] Adjust probabilities, probably only in callMutationBurden, not in fitting.