Computing considerations for large data set

[victoriaserelli]

Hi Keegan, Hoping you can help shed some insight on my issue. I have 94 samples (emseq) in my dataset, and I am trying to run dmrseq with the test covariate being a continuous variable. I always get stuck for a very long time at the first step: "Detecting candidate regions with coefficient larger than 0.1 in magnitude. Chromosome chr1" .. and does not progress any further.

Also experience the same scenario when i try to do multiple (more than 2) group comparisons (categorical test covariate with 3 or 4 levels). On the same machine, same data set, however I am able to run 2-group comparisons successfully.

Any thoughts on why this may be so? is this a matter of compute power?

Thanks in advance, vic