system is computationally singular

[zwj426]

Hi Jeff,

I tried to apply SVA to a set of data but encountered some problems. If I ran command svaObj <- sva(exper, mod, mod0, n.sv=n.sv), I received this error: Number of significant surrogate variables is: 427 Iteration (out of 5 ):1 Error in solve.default(t(mod) %*% mod) : system is computationally singular: reciprocal condition number = 5.55112e-18

dim(exper) 17346432 dim(mod) 4324 dim(mod0) 432*1 n.sv=427

I don't know how to solve it. Could you help me?

Thanks, Jie