10x visium spot proportion

[wang0430]

Hi,

Thank you very much for developing such an excellent tool for cell communication, especially for the spatial transcriptome.

I am recently using cellchat to analyze the interaction of spatial transcriptome data. Similar to the 10x visium sequencing method, it cannot achieve single-cell resolution, so each point is actually the proportion of cells of multiple cell types. Cellchat must select the cell type with the highest proportion as a representative and then continue the analysis, which may greatly affect the reliability of the results. I sent you an email last year to raise this issue, and the reply said that the weight will be increased in the near future, but it seems that there is still no update. Sorry to trouble you!

best wishes,

wanggl