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Draw the flux of tuberculosis organism with e.coli map

Open AgustinPardo opened this issue 5 years ago • 0 comments

Please include a short description of problem here

Hello,

I am running FBA using a mycobacterium tuberculosis model from BIGG (http://bigg.ucsd.edu/models/iEK1008).

After run FBA I using the e.coli map of the COBRA tutorial (https://opencobra.github.io/cobratoolbox/stable/tutorials/tutorialEcoliCoreModel_part1.html) to map the flux results: """ map=readCbMap('ecoli_Textbook_ExportMap.txt') options.zeroFluxWidth = 0.1; options.rxnDirMultiplier = 10; drawFlux(map, model, FBAsolution.x, options); """

I am new in the area and have some questions:

🚩 1) Is there some way to actualize the "ecoli_Textbook_ExportMap.txt" map to tuberculosis reactions/genes? Or anyone knows a map like the e.coli closer to tuberculosis organism pathways/reactions?

🚩 2) Do you think that e.coli draw flux map is a good approximation (biologically speaking) to draw the flux of tuberculosis? Should I take into account other technical aspects?

🚩 3) How I could check if some reactions of tuberculosis have a different id to e.coli map and they could not be drawn because they don't match the id of the map?

🚩 4) Is this (draw the fluxes result) the best way to debug my model an see if is working in the correct biology way?

Regards

I hereby confirm that I have:

  • [x] Tried to solve the issue on my own
  • [x] Retried to run my code with the latest version of The COBRA Toolbox
  • [x] Checked that a similar issue has not already been opened

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AgustinPardo avatar Sep 09 '20 18:09 AgustinPardo