Dan Nealschneider comments

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                                            Dan Nealschneider

GetSubstructMatches does not find all matches in large molecule

This was an issue with substructure search's MaxMatches parameter not being used by the recursive interior match. It was addressed in #6984.

text diffs on huge files are slow

OK!

Multiprocessing Pool Crash

I can trigger this traceback on Mac using Scalene version 1.5.51 (2025.01.27) and Python 3.11.4 if I add: ``` mp.set_start_method('spawn', force=True) ``` to @jadczak 's very clear reproducible. This is...

HetAtomTautomerv2 imine/enamine tautomer region too broad for aromatic imine

I do see that the transform generated from PT_03_00 has a different InChiKey, let's double check before closing this.

HetAtomTautomerv2 imine/enamine tautomer region too broad for aromatic imine

> > I do see that the transform generated from PT_03_00 has a different InChiKey, let's double check before closing this. > > So do the input and the 1st...

Smiles that can't be canonicalized - mega issue

As we work on these, we should be sure to test both `SetUseLegacyStereoPerception(true)` and `SetUseLegacyStereoPerception(false)`. Some issues only affect pathway, see for example #8712 and #8689