Using SIMBA with partially paired Multiome data

[ccruizm]

Good day!

I would like to know whether it is possible to use SIMBA in cases where one has partially paired data (some data has only scRNA, others only scATAC and some multiome (RNA+ATAC same cell).

Thanks in advance!

[huidongchen]

Good day!

I would like to know whether it is possible to use SIMBA in cases where one has partially paired data (some data has only scRNA, others only scATAC and some multiome (RNA+ATAC same cell).

Thanks in advance!

Thank you for your interest in SIMBA!

Yes, it is totally feasible to apply SIMBA to partially paired data and in fact, that's the case where SIMBA excels.

Essentially, SIMBA works as long as a connected graph can be constructed. I would recommend checking out our tutorials on scRNA-seq analysis, Multimodal analysis and Multiomics integration.