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Pip install openCV
Any idea how to fix this?
Pip version is up to date. Also did install scikit-build.

It's the usual problem: you can only install pure Python packages, since there is no compiler that is capable of creating a dynamic library that would be useable by Python.
Carnets (also on the AppStore) has OpenCV, and it makes more sense since you get to see the images as you work on them.