HoLLy.MemoryLib
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Look into Nt ReadProcessMemory
Should bypass a lot of checks, meaning scanning will be somewhat to a lot faster. At the very least, this is useful for sigscanning. Possibly not viable for normal accessing due to less checks.
Anecdotal evidence:

I have been informed that syscalls from ntdll are annoying, so this may be useful: https://github.com/Dewera/Pluto
Could also be useful: https://gist.github.com/michel-pi/eae4d9c16e2dce8737e2f7780b38bc31 (archive backup)