Patients with only one sample

[logan-leak]

In the vignette, it says "ClonEvol requires an input data frame consisting of at least a cluster column and one or more variant cellular prevalence columns, each corresponds to a sample." However, when I try to run the functions for a patient with only one sample (so the data frame only has two columns, one for the cluster number and one for the VAF value), I run into errors that appear to be unresolvable.

[hdng]

Hi @logan-leak,

This is a known issue with ClonEvol. At some point, the implementation of bootstrapping dropped support for single sample analysis. One trick to overcome this is to create two identical samples from a single sample and run ClonEvol, and then use the output of only one sample.

Does this work for your case?

[logan-leak]

Yes, that works. Thanks!