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Implement some heuristics to sanity check the tumor and normal matching

Open armish opened this issue 8 years ago • 0 comments

Things that can go wrong here include:

  • Mismatched sequencing platform
  • Sample mismatch/mix-up
  • ...

And these can easily lead to some unexpected variant calling behavior (e.g. having tens of thousands of filter-passing somatic variants). Potentially, metrics extracted from the BAM file (and during the QC process) might help with implementing such heuristics — e.g. read length, # of reads, information content...

armish avatar Jan 30 '17 03:01 armish