svtools icon indicating copy to clipboard operation
svtools copied to clipboard

lmerge/ prune workflow still results in overlapping calls

Open djakubosky opened this issue 7 years ago • 2 comments

Just wanted to bring up that running lsort/lmerge/prune pipeline seems to still result in a number of overlapping calls (>50% Reciprocal overlap for about 1000 variant pairs in my filtered call-set). I am curious as to if this behavior is expected. They don't tend to have similar AF (which is probably why they aren't merged but I am have been taking the set of breakpoints with the highest AF and removing others as my solution for now.

Let me know if you have any thoughts, Thanks!

djakubosky avatar May 01 '17 23:05 djakubosky

I wanted to add in this example as something I wouldn't expect after merging or pruning

image

this particular variant is found in mostly the same individuals, and overlaps >50%

djakubosky avatar May 02 '17 00:05 djakubosky

Hello, I have met the same problem, have you found the answer?

jxcao98 avatar Nov 09 '21 09:11 jxcao98