Possible SSL connectivity problems detected: How can I possibly fix this?

[Shrishtee-kandoi]

Error in curl::curl_fetch_memory(url, handle = handle) : SSL peer certificate or SSH remote key was not OK: [uswest.ensembl.org] SSL certificate problem: certificate has expired

[grimbough]

Which version of biomaRt are you using? You can find this with packageVersion('biomaRt').

The uswest mirror was retired fairly recently, and you'll need to use biomaRt version 2.57.1 or newer, where references to that mirror have been removed.