covid19-review icon indicating copy to clipboard operation
covid19-review copied to clipboard

Published 20 hours ago • verified publisher icon greenelab

Draft proposed updates to risk factors/social determinants of health section

Open rando2 opened this issue 3 years ago • 18 comments

Description of the proposed additions or changes

This is a work in progress that I'm posting so it's not secretly on my computer! The goal is to tie the social side and the clinical side together via allostatic load/inflammation

Related issues

Suggested reviewers (optional)

Checklist

  • [ ] Text is formatted so that each sentence is on its own line.
  • [ ] Pre-prints cited in this pull request have a GitHub issue opened so that they can be reviewed.

rando2 avatar Feb 24 '21 20:02 rando2

AppVeyor build 1.0.3421 for commit bd50890f405b38031c79720d20aac3dad67eba20 is now complete.

Found 48 potential spelling error(s). Preview:content/20.pharmaceuticals.md:724:AbbVie content/20.pharmaceuticals.md:724:ABVV content/20.pharmaceuticals.md:729:AbCellera content/20.pharmaceuticals.md:729:NIAID content/20.pharmaceuticals.md:735:Estesevimab content/20.pharmaceuticals.md:735:JS content/20.pharmaceuticals.md:736:Junshi content/20.pharmaceuticals.md:745:REGN content/20.pharmaceuticals.md:753:REGN content/20.pharmaceuticals.md:754:REGN content/20.pharmaceu...
The rendered manuscript from this build is temporarily available for download at:

AppVeyorBot avatar Feb 24 '21 20:02 AppVeyorBot

AppVeyor build 1.0.3439 for commit 9766c3d1e8553cda2903ef39826eeb718cb21ee6 is now complete....

Found 24 potential spelling error(s). Preview:content/40.inequality.md:1:Reprecussions content/40.inequality.md:9:acture content/40.inequality.md:31:interrelatedness content/40.inequality.md:33:allostatic content/40.inequality.md:34:allostatic content/40.inequality.md:37:acknowledgement content/40.inequality.md:38:recontextualize content/40.inequality.md:44:etiologically content/40.inequality.md:46:reflectance content/40.inequality.md:46:spectrophotometry content/40. The rendered manuscript from this build is temporarily available for download at:

AppVeyorBot avatar Mar 03 '21 20:03 AppVeyorBot

AppVeyor build 1.0.3446 for commit 65fe5a0eca39c613d1d5a9700cab4348b8de9c4a is now complete.

Found 2 potential spelling error(s). Preview:content/40.inequality.md:37:acknowledgement content/40.inequality.md:51:maladaptive...
The rendered manuscript from this build is temporarily available for download at:

AppVeyorBot avatar Mar 03 '21 21:03 AppVeyorBot

AppVeyor build 1.0.3449 for commit 5052074c613200e1be64c8d95888a40079fc6604 is now complete.

Found 0 potential spelling error(s). Preview:...
The rendered manuscript from this build is temporarily available for download at:

AppVeyorBot avatar Mar 03 '21 22:03 AppVeyorBot

AppVeyor build 1.0.3460 for commit 265daeaa0ee059b9ea0ff0a0ebb31d892dc31346 is now complete.

Found 0 potential spelling error(s). Preview:...
The rendered manuscript from this build is temporarily available for download at:

AppVeyorBot avatar Mar 05 '21 17:03 AppVeyorBot

AppVeyor build 1.0.3532 for commit be12fee9e5e47043b193035033cac334d65bac15 is now complete.

Found 0 potential spelling error(s). Preview:...
The rendered manuscript from this build is temporarily available for download at:

AppVeyorBot avatar Mar 09 '21 16:03 AppVeyorBot

@juliettemarie0405 can you check your author information that I added? Just leave notes for anything you want filled in or that is wrong and I can fix it -- also, just note that you are in agreement with the code of conduct and whether you have any conflicts of interest! (I know you also sent me an email about this, I'm sorry I've been so behind!)

(Author order is determined at the end, so I put 0 for a placeholder, lol)

rando2 avatar Mar 24 '21 21:03 rando2

AppVeyor build 1.0.3819 for commit 5bae9eeb14ea2f84a72a1e7bd1056624995bc858 failed.

AppVeyorBot avatar Mar 24 '21 21:03 AppVeyorBot

@juliettemarie0405 can you check your author information that I added? Just leave notes for anything you want filled in or that is wrong and I can fix it -- also, just note that you are in agreement with the code of conduct and whether you have any conflicts of interest! (I know you also sent me an email about this, I'm sorry I've been so behind!)

(Author order is determined at the end, so I put 0 for a placeholder, lol)

just did!

juliettemarie0405 avatar Mar 25 '21 03:03 juliettemarie0405

AppVeyor build 1.0.3825 ... for commit c90a4fb359ecc0b9fdd9aae8b112b1cd32781b41 is now complete.

Found 1 potential spelling error(s). Preview:content/22.vaccines.md:361:IgGs The rendered manuscript from this build is temporarily available for download at:

AppVeyorBot avatar Mar 25 '21 14:03 AppVeyorBot

This isn't directly about COVID-19 or inflammation, but might be useful to cite: https://www.rwjf.org/en/library/research/2021/03/black-patients-are-more-likely-than-white-patients-to-be-in-hospitals-with-worse-patient-safety-conditions.html

dziakj1 avatar Mar 29 '21 13:03 dziakj1

Also, it looks like at least some people have done some research into why higher-BMI patients do worse with COVID-19. The relationship holds up even in an all-white subsample, so it isn't just confounding by racial background. https://www.frontiersin.org/articles/10.3389/fgene.2020.586308/full https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521361/

dziakj1 avatar Mar 29 '21 13:03 dziakj1

@rando2 I found this preprint talking about allostatic load as a mediator, although it appears to be more of a narrative review rather than a new study: https://www.medrxiv.org/content/10.1101/2021.01.24.21250397v1.full.pdf

dziakj1 avatar Mar 29 '21 18:03 dziakj1

This paper just came out. It is a rather fancy causal mediation analysis of British data, arguing that a sizable reason for racial differences in COVID rates in the UK is "material disparities" (economic poverty). It uses some rather difficult statistical methods that I've only started to learn about myself, so if you are interested, I'd try to write a paragraph on it. However, it depends on what you want to do with this paper and I don't know whether it would fit in or not.
https://academic.oup.com/eurpub/advance-article/doi/10.1093/eurpub/ckab041/6179315

dziakj1 avatar Apr 03 '21 16:04 dziakj1

Also, this preprint looks at seropositivity rates in different demographic groups in the US last year, which might help to provide a look at overall infection rates including mild cases. For example, the rates were higher in younger than older participants, and in female than male participants; even though if you counted deaths the risks would be higher for older than younger and for male than female. The Black/African American demographic was very disproportionately affected.
https://pubmed.ncbi.nlm.nih.gov/33532807/ The data is a bit old though.

dziakj1 avatar Apr 03 '21 17:04 dziakj1

Hello @rando2 and @RLordan ! I don't know how to work this in, but I think it's very related to inflammation. This very new JAMA Pediatrics paper with a large sample provided evidence that MIS-C in children was due to a "delayed" immune reaction to covid-19. They also mentioned in passing that most children with this syndrome were Black or Hispanic -- although that doesn't necessarily mean that they are more vulnerable to MIS-C per se, it just might be that they are more likely to get COVID or more severe COVID, and the MIS-C may follow later. I know very little about inflammation but my rough understanding is that it has to do with the immune system. I feel like this paper is really important but am somewhat deficient in the skills I would need to explain it. If you like, I could put one of my short and vaguely worded sentences, that are just wrappers for citations, in there somewhere. But somebody who knows about immunology could do better. Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic Ermias D. Belay, MD; Joseph Abrams, PhD; Matthew E. Oster, MD; et al. https://jamanetwork.com/journals/jamapediatrics/fullarticle/2778429 The paper is discussed in an editorial here: https://jamanetwork.com/journals/jamapediatrics/fullarticle/2778430

dziakj1 avatar Apr 08 '21 16:04 dziakj1

Hello again! Another large report about inequities has come out, this one in the Annals of Internal Medicine on April 20: COVID-19 Inequities Across Multiple Racial and Ethnic Groups: Results From an Integrated Health Care Organization https://www.acpjournals.org/doi/10.7326/M20-8283

dziakj1 avatar Apr 24 '21 00:04 dziakj1

This is ANOTHER new large study from the UK: Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England: an observational cohort study using the OpenSAFELY platform https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00634-6/fulltext

dziakj1 avatar May 04 '21 14:05 dziakj1