New Paper (Other): Inflammasome activation in infected macrophages drives COVID-19 pathology

[dziakj1]

Title: Inflammasome activation in infected macrophages drives COVID-19 pathology

General Information

Please paste a link to the paper or a citation here:

Link: https://www.nature.com/articles/s41586-022-04802-1_reference.pdf

What is the paper's Manubot-style citation?

Citation: @doi:10.1038/s41586-022-04802

Is this paper primarily relevant to Background or Pathogenesis?

• [ ] Background
• [x] Pathogenesis
• [ ] Methods

Please list some keywords (3-10) that help identify the relevance of this paper to COVID-19

• inflammation
• cytokines
• inflammasomes

Please note the publication / review status

• [ ] Pre-print
• [x] New Peer-Reviewed Paper
• [ ] Peer-Reviewed Paper Pre-2020

Which areas of expertise are particularly relevant to the paper?

• [ ] virology
• [ ] epidemiology
• [ ] biostatistics
• [x] immunology
• [ ] pharmacology
• [ ] other:

Summary

Suggested questions to answer about each paper:

• What did they analyze?
• What methods did they use?
• Does this paper study COVID-19, SARS-CoV-2, or a related disease and/or virus?
• What is the main finding (or a few main takeaways)?
• What does this paper tell us about the background and/or diagnostics/therapeutics for COVID-19 / SARS-CoV-2?
• Do you have any concerns about methodology or the interpretation of these results beyond this analysis?

Any comments or notes?