remaining issues with hormone roles

[krchristie]

placeholder ticket to go through remaining issues with hormone terms

[cmungall]

Let's distinguish between "hormone-P" terms and term for subtypes of hormone, e.g. {estrogen,auxin}-P

I think your excellent analysis showed that we should just treat estogen as rigid

I believe we should do the same for auxin, treat as rigid

The hormone-P terms are more difficult. I think some such as hormone secretion could be better phrased in a more GO-like way (e.g secretion involved in signaling), but looking at current annotations for this I'm skeptical of the value of this term as either a grouping or as a term to use in direct annotation

note:

id: GO:0046879 name: hormone secretion namespace: biological_process def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732] is_a: GO:0009914 ! hormone transport is_a: GO:0023061 ! signal release

doesn't even have a chebi axiomatization (which is fair enough given problems this has caused, but it shows how inconsistently we applied these patterns in the past), and lacks parentage to GO:0046903 ! secretion, which is an accidental omission.

[pgaudet]

On the immunology calls we noticed that regulated secretion is a problem.

'x secretion' should not exist, as the secretory mechanism is no different for one compound to another. 'Regulation of secretion' is OK, in cases where there is regulated secretion. See also Fig 4 is this review: https://ashpublications.org/blood/article/118/1/9/28431/Cytokine-release-from-innate-immune-cells

Thanks, Pascale

[pgaudet]

I think we can already obsolete

• GO:0042445 hormone metabolic process
• GO:0046885 regulation of hormone biosynthetic process
• GO:0032353 negative regulation of hormone biosynthetic process
• GO:0046886 positive regulation of hormone biosynthetic process