TreeGrafter issue PANTHER:PTHR10333:SF42

[ValWood]

UniProtKB:O74736 | png2 | enables | GO:0004402    histone acetyltransferase activity | ECO:0007826   IEA | GO_REF:0000118 | PANTHER:PTHR10333:SF42 | 284812 Schizosaccharomyces pombe (strain 972 / ATCC 24843) | TreeGrafter

Png2 is a  histone acetyltransferase subunit, but it doesn't have histone acetyltransferase activity.

Need to track down/report originating annotation.

[ValWood]

@pgaudet this is an example with no IBA (there are lot of these)

[pgaudet]

Thanks @ValWood

I checked the PAINT annotations, and we dont have that MF; however there is an IBA to GO:0033698 Rpd3L complex, which is a child of histone deacetylase complex, which itself has a relation [capable of] some[histone deacetylase activity] (you can view this in OLS).

I suspect this is where this annotation is coming from.

[ValWood]

We don't propagate these though do we? At least I have never seen it.

[pgaudet]

In this case it would be a question for @alexsign - do these get propagated in the GOA pipeline?

At GO central TBH I am not sure what we do. On the list...

[ValWood]

It's odd because if they were propagated, I would have 1000s for complex members. Maybe it's based on an annotation that has been subsequently removed....

[pgaudet]

@alexsign says that interontology links would NOT come from TreeGrafter as the source, so my hypothesis was incorrect.

[pgaudet]

@dustine32 It is possible to check in the PAINT database whether UniProtKB:O74736 ever had an annotation to GO:0004402 histone acetyltransferase activity ?

[dustine32]

@pgaudet No GO:0004402 in the PAINT Curation DB. I only see these terms annotated to UniProtKB:O74736:

GO:0035064	IBA
GO:0005829	HDA
GO:0033698	IBA
GO:0033698	IDA
GO:0005634	IBA
GO:0005634	HDA
GO:0006355	IBA
GO:0140861	IC

[pgaudet]

Is this current? Or does that cover all the history?

[dustine32]

@pgaudet Yes, this is current and covers all history. There doesn't appear to be any previously obsoleted GO annotation to this protein.