dunovo
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Change defaults in 3.0
Version 3.0 offers an opportunity to change some default settings. Let's list them here.
make-consensi.py
--aligner
: biopython
Currently it's swalign
, an esoteric Smith Waterman implementation.
That'll require BioPython as a dependency, though.
- Ideally version 1.75 at least
--cons-thres
: 0.7
Currently set to 0.5
, but it should default to the threshold recommended by the duplex sequencing designers in Kennedy et al. 2014 (page 4).
correct.py
--dist
: 3
Currently it's 1
, but a more aggressive setting is still pretty safe. I've already changed the default in the Galaxy tool.
Re-opening with the addition of --cons-thres
to the list.