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Age of onset filter

Open damiansm opened this issue 6 years ago • 2 comments

Should we somehow have a disease-level age of onset filter one day i.e. if we know the genome is from a newborn don't highlight a phenotype match based on Parkinson's disease etc!

Slightly less silly versions of this are sometimes the reason the clinicians reject an Exomiser candidate when I present it to them and would be cool to automate somehow

damiansm avatar Mar 09 '18 11:03 damiansm

We'd need more information about the patient in order to do this. Something like a phenopacket would fit the bill. Assuming age of onset of each phenotype term is provided it would also allow for much more accurate disease diagnosis.

julesjacobsen avatar Mar 13 '19 17:03 julesjacobsen

Requires #373

Will also need changes to : [ ] disease_hp table schema, [ ] disease DAO [ ] disease model [ ] update to Sample to include Age/Onset, PhenotypicFeature [ ] signature change to Prioritiser to accept a Sample. [ ] update to HiPhive logic to filter out mismatched diseases for a patient

julesjacobsen avatar Jul 04 '23 17:07 julesjacobsen