How to normalise different sequencing coverage samples in CNVKit?

Open tanbiswas opened this issue 2 years ago • 1 comments

Hi I'm using CNVKit to identify copy number alterations using WES data. However, our tumor samples have a coverage of 200x and corresponding normal samples have a coverage of 100x. So, is there a way to normalize the coverage before calling CNV using CNVKit?

Please let me know hoe to proceed.

Jun 16 '23 05:06 tanbiswas

Hi, I am having the same question. We are using a panel of normal samples with 100x coverage as the reference for each tumor sample with a coverage of 300x. I would appreciate if someone could help. Thanks

Nov 27 '23 18:11 bahreinia