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Consider adding ECO classes to describe the evidence (assays) for observable outcomes

Open jmillanacosta opened this issue 1 year ago • 1 comments

Some classes and properties from the Evidence and Conclusion Ontology (ECO) could be added to the ontology to support linking observable outcomes to their evidence (an assay, a reference, etc.). I see a direct application in the SbD4Nano assertion network, where an assay involving certain assay specifications, a material, a cell line/animal model, etc. is supporting evidence for an assertion (e.g., dose correlates with toxicity).

https://www.ebi.ac.uk/ols4/ontologies/eco

curation method for the assertions:

manual assertion
http://purl.obolibrary.org/obo/ECO_0000218

An assertion method that involves human review.

A manual assertion could be based on evidence that is generated by and interpreted by a human or it could involve human review of computationally generated information.

the assay has role:

experimental evidence used in manual assertion
http://purl.obolibrary.org/obo/ECO_0000269

A type of experimental evidence that is used in a manual assertion.

the assertion is a:

conclusion based on data (Imported)
http://purl.obolibrary.org/obo/OBI_0001909

An information content entity that is inferred from data.

jmillanacosta avatar Feb 16 '24 09:02 jmillanacosta

Yes, please go ahead. We have the intention to start using ECO in WikiPathways soon too. (BTW, you may want to ask Marvin if he has been using it already for the AOP-Wiki RDF.)

egonw avatar Feb 16 '24 14:02 egonw