vitamin c

[muthuvenkat]

Vitamin C (ascorbic acid, CHEBI:29073 and ascorbate, CHEBI:38290) are (non-validated) children of cofactor. They are not prsthetic groups but used to reduce oxidized sites in other prsthetic groups (ref: 2057141, last sentence), which means it must go in and out of active sites. Therefore I suggest to either create a head entity (e.g. vitamin c) with children 29073 and 38290 and make it a child of coenzyme, or to shift the two entities directly under coenzyme.

Reported by: grotten_olm

[muthuvenkat]

Logged In: YES user_id=2048260 Originator: NO

A heading for vitamin C is also needed from the nutritional point-of-view; it will also include L-dehydroascorbic acid. Thus the hierarchy should be: -water-soluble vitamin (CHEBI:27314) --vitamin C ---L-ascorbic acid (CHEBI:29073) ---L-dehydroascorbic acid (CHEBI:27956)

A question arises over whether L-ascorbate should also be a child of vitamin C. It might be better to rely on the relation: L-ascorbate (CHEBI:38290) is conjugate base of L-ascorbic acid (CHEBI:29073) to reflect this, because the direct children of a vitamin entity should perhaps be restricted to the separate contributors to the vitamin activity. Addition of the vitamin heading could allow the inexact synonym of 'Vitamin C' under L-ascorbic acid to be removed.

Original comment by: unwin305

[muthuvenkat]

Logged In: YES user_id=802919 Originator: NO

I have created the following relationships:

vitamin C (CHEBI:21241) is a water-soluble vitamin (CHEBI:27314) L-ascorbic acid (CHEBI:29073) is a coenzyme (CHEBI:23354) L-ascorbic acid (CHEBI:29073) is a vitamin C (CHEBI:21241) L-dehydroascorbic acid (CHEBI:27956) is a coenzyme (CHEBI:23354) L-dehydroascorbic acid (CHEBI:27956) is a vitamin C (CHEBI:21241)

I have removed relationships from CHEBI:29073 and CHEBI:38290 to cofactor.

Kirill

Original comment by: kiri11

[ddooley]

What happened to these two axioms? I don't see the subclasses in Chebi... L-dehydroascorbic acid (CHEBI:27956) is a vitamin C (CHEBI:21241) L-ascorbic acid (CHEBI:29073) is a vitamin C (CHEBI:21241) Thanks, Damion

[ddooley]

Also there is a problem with putting "Vitamin C" and "B Vitamin" under role, but all the other vitamins are under molecular entity. Any vitamin entity under role I would recommend have the suffix "role". This would mean that you need to rername the above. Then create new Vitamin C and B Vitamin entries as material entities which have subclasses of the particular molecules accepted in their group?

[LilyAndres]

Hi I'm trying to follow this subject with another question.

Why 'vitamin C' and 'B vitamin' have 'is a' relationship to 'water-soluble vitamin' but vitamins D,K,E and A have the relationship 'has role' 'fat-soluble vitamin'.

Also, I can't find L-ascorbic acid (CHEBI:29073) is a vitamin C (CHEBI:21241).